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Muscle Pathophysiology and Regeneration

Research on muscle biology focuses on preserving strength and functionality during aging and developing innovative therapies for genetic muscle diseases.
Our Scientists

Bert Blaauw

  • Principal Investigator
  • Fisiopatologia e Rigenerazione Muscolare

Maria Pennuto

  • Principal Investigator
  • Ricerca Oncologica Avanzata, Fisiopatologia e Rigenerazione Muscolare, Cervello e Sistema Nervoso

Marco Sandri

  • Principal Investigator
  • Ricerca Oncologica Avanzata, Fisiopatologia e Rigenerazione Muscolare

Luca Scorrano

  • Principal Investigator
  • Ricerca Oncologica Avanzata, Fisiopatologia e Rigenerazione Muscolare, Cervello e Sistema Nervoso

Carlo Viscomi

  • Principal Investigator
  • Ricerca Oncologica Avanzata, Fisiopatologia e Rigenerazione Muscolare, Cervello e Sistema Nervoso

Francesco Chemello

  • Principal Investigator
  • Medicina Rigenerativa e Tecnologie Avanzate, Fisiopatologia e Rigenerazione Muscolare

Vanina Romanello

  • Ricercatore non strutturato
  • Fisiopatologia e Rigenerazione Muscolare

Latest Discoveries

The hallmarks of skeletal muscle health.

2026 - Nature Metabolism

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  • Fisiopatologia e Rigenerazione Muscolare

Mytho/Phaf1 is required to prevent DNA damage and tissue degeneration in Danio rerio.

2026 - Cell Death Discov.

Marco Sandri

Principal Investigator

  • Fisiopatologia e Rigenerazione Muscolare

Androgen receptor and its coregulators in sex-biased diseases.

2025 - Trends in Molecular Medicine

Maria Pennuto

Principal Investigator

  • Fisiopatologia e Rigenerazione Muscolare

Protocol for measuring force in skinned diaphragm muscle fibers of myopathic SEPN1 knockout mice following chronic tauroursodeoxycholic acid treatment.

2025 - STAR Protoc.

Bert Blaauw

Principal Investigator

  • Fisiopatologia e Rigenerazione Muscolare

The evolution of eukaryotic linear motifs governing the function of androgen receptor from fish to Homo sapiens.

2025 - Nucleic Acids Res.

Maria Pennuto

Principal Investigator

  • Fisiopatologia e Rigenerazione Muscolare

Opantimirs: A class of antagonizing microRNAs that upregulate Opa1 and improve mitochondrial and disuse myopathies.

2025 - Cell Rep Med

Luca Scorrano

Principal Investigator

  • Fisiopatologia e Rigenerazione Muscolare

Kv3 channel agonist ameliorates the phenotype of a mouse model of amyotrophic lateral sclerosis.

2025 - Acta Neuropathol Commun.

Maria Pennuto

Principal Investigator

  • Fisiopatologia e Rigenerazione Muscolare

Autophagy in Skeletal Muscle

2024 - Cold Spring Harbor perspectives in biology

Marco Sandri

Principal Investigator

  • Fisiopatologia e Rigenerazione Muscolare

Autophagy in Skeletal Muscle.

2025 - Cold Spring Harb Perspect Biol.

Marco Sandri

Principal Investigator

  • Fisiopatologia e Rigenerazione Muscolare

Protocol for measuring force in skinned diaphragm muscle fibers of myopathic SEPN1 knockout mice following chronic tauroursodeoxycholic acid treatment.

2025 - STAR Protoc.

Bert Blaauw

Principal Investigator

  • Fisiopatologia e Rigenerazione Muscolare

Modelling POLG mutations in mice unravels a critical role of POLγΒ in regulating phenotypic severity.

2025 - Nat Commun.

Carlo Viscomi

Principal Investigator

  • Fisiopatologia e Rigenerazione Muscolare, Cervello e Sistema Nervoso

A combined experimental and computational analysis of mantATP turnover in skinned muscle fibers.

2025 - Proc Natl Acad Sci U S A

Bert Blaauw

Principal Investigator

  • Fisiopatologia e Rigenerazione Muscolare

Neural stimulation suppresses mTORC1-mediated protein synthesis in skeletal muscle

2025 - Sci Adv.

Bert Blaauw

Principal Investigator

  • Fisiopatologia e Rigenerazione Muscolare, Cervello e Sistema Nervoso

The novel use of the CFTR corrector C17 in muscular dystrophy: pharmacological profile and in vivo efficacy.

2025 - Biochemical Pharmacology | Journal

Bert Blaauw

Principal Investigator

  • Fisiopatologia e Rigenerazione Muscolare

Reduced ATP turnover during hibernation in relaxed skeletal muscle.

2025 - Nat Commun.

Bert Blaauw

Principal Investigator

  • Fisiopatologia e Rigenerazione Muscolare

Salbutamol repurposing ameliorates neuromuscular junction defects and muscle atrophy in Col6a1-/- mouse model of collagen VI-related myopathies

2024 - Clinical and Translational Medicine

Bert Blaauw

Principal Investigator

  • Fisiopatologia e Rigenerazione Muscolare

Support Our Research

Donate now

Support Our Research

Donate now