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Luca Scorrano is a pioneer in the study of mitochondrial dynamics. His research has redefined fundamental concepts in mitochondrial biology and apoptosis, introducing the role of an important protein called OPA1 in modulating the morphology of mitochondrial cristae. With a translational vision, his laboratory explores how mitochondrial shape influences health, disease, and therapeutic response, with significant implications in fields such as cancer, neurodegenerative diseases, and metabolism.
Luca Scorrano’s research has revolutionized knowledge about mitochondria, the “powerhouses” of the cell. He has shown how their internal shape controls energy production, the ability of cells to survive or die, and their response to damage. He discovered the fundamental role of a protein called OPA1, which helps mitochondria defend and adapt themselves in cases of stress or disease. His group has also studied how mitochondria communicate with other parts of the cell, contributing to a better understanding of many vital processes. Today, he focuses on finding new therapies for mitochondrial diseases, cancer, and cellular aging, supported by major European and national grants.
Mitochondria-membranous organelle contacts at a glance.
Sweetening mitochondria: Hexokinase shields mitochondria from fission when glucose is low.
2000
PhD in Bioenergetics
2000-2003
Research Fellow - Harvard Medical School, Dana-Farber Cancer Institute, Boston, MA (USA)
2003-2007
Telethon Researcher - Istituto Telethon-Dulbecco
2007-2023
Full Professor – Department of Cellular Physiology and Metabolism – Geneva (Switzerland)
2014-2020
Scientific Director - VIMM
2013 - present
Full Professor of Biochemistry - Università degli Studi di Padova
2006
EMBO Young Investigator Award
2011
Chiara D’Onofrio Award, Chiara D’Onofrio Foundation – SIBBM (Italian Society of Biochemistry and Molecular Biology)
2012
Elected Member of EMBO
2013
Award for Excellence in Basic/Translational Research, European Society for Clinical Investigation
2019
Elected Member of Academia Europaea
2023
1st Margaret Reed Lewis Award for Excellence in Mitochondrial Research, GRC Mitochondria
2024
Career Award in Research 2024, International Society for Heart Research (ISHR)
2024
One of the World’s Most Cited Researchers 2024
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