November 29, 2018 h 5pm
Palazzo Bo, Via VIII Febbraio – Padova
‘Inflammaging: chronic inflammation and diseases of old age, including frailty and sarcopenia’
Prof. Rosario Rizzuto, Rettore Università degli Studi di Padova
Prof. Francesco Pagano, Presidente Fondazione Ricerca Biomedica Avanzata VIMM
Prof. Claudio Franceschi, Professore Emerito dell’Università di Bologna e Direttore del Centro Nazionale Italiano per le ricerche dell’anziano
Modera: Professor Luca Scorrano, Direttore Scientifico VIMM
Discussant: Professor Bert Blaauw e Professor Marco Sandri, Principal Investigator VIMM
Author of 720 scientific publications, the Professor Franceschi has identified the most important characteristics of immunosenescence, which he defined with the term inflammaging. During his speech ‘Inflammaging: chronic inflammation and diseases of old age, including frailty and sarcopenia‘ he will illustrate the mechanisms that are at the basis of inflammaging and that contribute significantly to the pathologies of senescence and mortality. Research aimed at identifying risk factors such as genetic factors and lifestyles, which influence the evolution of senescence will be exhibited.
Advanced age in humans is in fact related to chronic low-intensity inflammation that can induce frailty and sarcopenia with often harmful outcomes. These risk factors are due to age-related degenerative processes, such as the alteration of the cell death program or the intestinal microbiome. On the more or less rapid evolution of these processes, it is necessary to distinguish the role of genetic factors and that of lifestyles. It is therefore necessary to identify markers capable of distinguishing the roles of these risk factors, thus identifying high-risk individuals.