What is the impact of diabetes and metabolic diseases on stem cell kinetics?
Which are the consequences of an altered bone marrow stem cell biology in diabetes?
Diabetes is the most common metabolic disease and it shortens life expectancy owing to multi-origan chronic complications affecting the eyes, kidneys, nerves, heart and vessels. We are interested in the mechanisms and consequences of bone marrow structural and functional alterations in diabetes. The bone marrow contains stem cells and is site of hematopoiesis. Diabetes compromises stem cell mobilization and alters the phenotype of several leukocytes types. Understanding the causes and clinical implications of these changes is our challenge.
Diabetes is progressively growing worldwide with epidemic diffusion. Its prevalence reaches up to 10% of the general population in Western countries, and it is growing even faster in the developing world. Importantly, diabetes leads to severe multi-organ complications and is associated with a shortened life expectancy. Diabetes develops as a consequence of a complex interplay between genes and environment. The metabolic alterations observed in diabetes promote the development of chronic complications within several organs, including the arteries, heart, kidneys, nerves and eyes. In turn, these are responsible for the high burden of morbidity and mortality in diabetic patients. In the Laboratory of Experimental Diabetology, research activities are focused on the cellular and molecular mechanisms underlying the development of diabetes and its long-term complications, as well as the therapeutic strategies to prevent and treat these conditions. In the Lab, expertise from multiple disciplines converge to increase the impact of the work, including clinical medicine and basic science.
The specific commitment of this Lab is to integrate basic science with clinical medicine, creating a unique environment, ideal to provide significant advancements in the field, through approaches of “translational medicine”. The group comprises a set of medical doctors, research fellows, as well as lab personnel with extensive experience in molecular and cellular biology, in silico studies, tissue analysis, and animal models of disease. Our major goal is to study how the bone marrow and stem cells are affected by diabetes and contribute to the development of metabolic abnormalities and chronic complications.
GIAN PAOLO FADINI
- MD: University of Padua (2004)
- PhD: University of Padua (2013)
- Group leader: Veneto Institute of Molecular Medicine, (2015-current)
- Assistant Professor of Endocrinology, University of Padua, Department of Medicine (2010-2015)
- Associate Professor of Endocrinology, University of Padua, Department of Medicine (2016-2022)
- Full Professor of Endocrinology, University of Padua, Department of Medicine
- 2008 – Morgagni prize silver medal
- 2009 – EASD Rising Star
- 2014 – Italian Diabetes Society Alcmeone Prize
- 2015 – “2003 Group” Prize
- 2020 – Minkowski Prize
- Gilead Fellowship