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The research group led by Professor Elvassore identified several cellular subpopulations and their interactions by leveraging the high efficiency of cellular reprogramming in microfluidics combined with time-resolved multi-omic analysis.
Through secretome analysis and single-cell transcriptomics, the team identified cellular subpopulations involved in the reprogramming process, in which the HGF/MET/STAT3 axis plays a key role as a potent enhancer of reprogramming. This mechanism operates through the accumulation of HGF (hepatocyte growth factor) within the confined microfluidic system, suggesting that human cellular reprogramming is a transcription factor–driven process that strongly depends on the extracellular context and on specific cell populations.
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