Gian Pietro Semenzato

Clinician
Clinico

Gianpietro Semenzato’s scientific activity focuses on the study of blood and immune system diseases, with particular attention to chronic leukemias and large granular lymphocyte leukemias (T-LGL). He has made decisive contributions to clarifying the molecular and immunological mechanisms that regulate the progression of these pathologies and their connection with the immune system. His studies have opened new perspectives for the development of targeted therapeutic strategies that combine expertise in hematology, immunology, and molecular biology.

Group members
Research

Gianpietro Semenzato, hematologist, has focused his research on rare leukemias that affect lymphocytes, key cells of the immune system. In particular, he has investigated how specific genetic mutations — especially in the STAT3 and STAT5B genes — promote the development of these diseases. Thanks to his studies, new biological markers have been identified that help to better recognize these leukemias and distinguish them from other similar disorders. This work has also had a direct clinical impact, paving the way for more accurate diagnoses and for targeted therapies designed to adapt to the characteristics of each individual patient.

Publications
  1. T-cell clones of uncertain significance. When is the rogue clone dangerous?

    Semenzato G, Teramo A, Calabretto G, Zambello R.Haematologica. 2025 Jan 1;110(1):37-46. doi: 10.3324/haematol.2024.286023.

  2. The constitutive activation of STAT3 gene and its mutations are at the crossroad between LGL leukemia and autoimmune disorders.

    Semenzato G, Calabretto G, Teramo A, Gasparini VR, Rampazzo E, Barilà G, Zambello R.Blood Cancer J. 2024 Jan 18;14(1):13. doi: 10.1038/s41408-024-00

  3. Not all LGL leukemias are created equal.

    Semenzato G, Calabretto G, Barilà G, Gasparini VR, Teramo A, Zambello R.Blood Rev. 2023 Jul;60:101058. doi: 10.1016/j.blre.2023.101058. Epub 2023 Feb 20.

  4. All that glitters is not LGL Leukemia.

    Semenzato G, Teramo A, Calabretto G, Gasparini VR, Zambello R.Leukemia. 2022 Nov;36(11):2551-2557. doi: 10.1038/s41375-022-01695-x. Epub 2022 Sep 15.

  5. Interrogating molecular genetics to refine LGLL classification.

    Semenzato G, Zambello R. Blood. 2022 May 19;139(20):3002-3004. doi: 10.1182/blood.2021015301.

Curriculum

1990

Associate Professor - Università degli Studi Padova

1995 - 2020

Director of Hematology and Clinical Immunology, Università di Padova

1998 –2003

Director of the Postgraduate School in Allergy and Clinical Immunology

2000 – 2020

Director of the Postgraduate School in Hematology, Università di Padova

2008 – 2011

President of the Italian Society of Immunology and Clinical Immunology

2009 – 2011

Director of the Department of Clinical and Experimental Medicine

2021 - present

Professor Emeritus at the University of Padua